Forever Young: The Science of Nutrigenomics for Glowing, Wrinkle-Free Skin and Radiant Health at Every Age

Dr. Perricone’s FOREVER YOUNG makes an extraordinary promise: by following a program designed to decrease wrinkles and dramatically improve the appearance of the skin, the reader is also guaranteed more energy, less fat and an improved mood.  The core of Dr. Perricone’s appeal is his scientific grounding and authority.  In a field notorious for the triumph of style over substance, Dr. Perricone is at the cutting edge of new science which is scientifically proven to work.    At the core of the new book is an exciting new science on skin:  Nutrigenomics and gene expression. With his innovative vision, Dr. Perricone has applied the new science to ease wrinkles, make the skin supple, smooth and glowing.  His prescriptive program will shave years off the reader's appearance and will give the reader more energy.

Amazon Sales Rank: #30124 in Books Published on: 2010-09-14 Released on: 2010-09-14 Original language: English Number of items: 1 Dimensions: 1.11" h x 6.28" w x 8.90" l, 1.55 pounds Binding: Hardcover 368 pages ISBN13: 9781439177341 Condition: New Notes: BRAND NEW FROM PUBLISHER! 100% Satisfaction Guarantee. Tracking provided on most orders. Buy with Confidence! Millions of books sold!

From Publishers Weekly Celebrity dermatologist Perricone (The Perricone Prescription) claims to have the key to blocking age-related illness while achieving youthful skin and energy. Based on nutrigenomics, an emerging field linking nutrition and longevity, his plan claims to activate age-reversing genes and biochemicals with superfoods (e.g., wild salmon, watercress, chia seeds, barley grass, cinnamon, cocoa); supplements (e.g., vitamins K and D, astaxanthin, Pycnogenol); a fat-burning diet with recipes; yoga; and rest. While other recent titles--particularly Michael Roizen and Mehmet Oz's YOU: Staying Young--echo such counsel, Perricone takes a beeline approach, backed by new technologies (Perricone's own Cold Plasma cream) and noninvasive skin treatments (micro-current). A resource list directs readers to Perricone-brand or promoted products (Williams-Sonoma cookbooks, Le Creuset cookware, etc.). Many favorite foods are forbidden in exchange for ageless beauty without chronic dieting and excessive workouts. After a few days free of dietary devils, readers might even embrace Perricone's model of success: Madonna and her salmon retox. Copyright © Reed Business Information, a division of Reed Elsevier Inc. All rights reserved. Review “I am a huge fan of Dr. Perricone and his philosophy ‘true beauty is radiant health.’ In Forever Young, you will discover the keys to that kingdom, the miracle foods and nutrients for a fabulously rejuvenated face and body. Thank you Dr. Perricone!” –Eva Mendes, internationally acclaimed actress and philanthropist“There are a lot of things about Dr. Perricone’s science that really resonate with me. Here is one of them: growing up Italian has kept me in touch with the magical properties of olive oil. Dr. Perricone has taken this and others to a new level!” –Steven Tyler, lead singer, Aerosmith“From his vitamin line to his superb skin care products, Dr. Perricone has not only helped me look better but has improved my overall quality of life.” –Uma Thurman“Dr. Perricone's years of clinical and laboratory research have resulted in technological breakthroughs.” —Harry G. Preuss, MD, professor of medicine, Georgetown University“Always ahead of the crowd, Dr. Nicholas Perricone takes another giant leap—this time into the science of Nutrigenomics. In Forever Young he teachers readers how to alter their gene expression through a variety of novel nutrients. By turning off inflammatory markers you can prevent disease and enjoy beautiful radian skin. Highly recommended.” –Harry G. Preuss, MD, MACN, CNS, professor of Physiology, Medicine and Pathology, Georgetown University Medical Center“Pioneering scientist, inventor and dermatologist, Dr. Nicholas Perricone’s latest field of research is Nutrigenomics. This fascinating new science demonstrates how we can alter our genetic blueprint for total face and body rejuvenation. Forever Young shows how we can overcome heredity and reinvent ourselves for the better—both inside and out.” –Elaine D’Farley, Beauty Director, SELF Magazine Excerpt. © Reprinted by permission. All rights reserved. Chapter OneTHE ICU:A NEW ANTIAGING RESEARCH LABORATORY The day had dawned cold and gray with a lowering sky on the morning of February 16. The dark, angry waves of the Long Island Sound dashed against the rocks, a harbinger of worse to come. Another snowstorm was scheduled for New York and Connecticut, making the winter of 2010 one for the record books from Florida to Maine. Escaping to the tropics was on my mind, but duty called. This was the day I was turning in the manuscript for my new book, Forever Young. I was proud to have written a book that broke new ground yet apprehensive, because the science might be considered cumbersome. I knew that there was no other way to tell the story. People needed strategies to stop the deadly degenerating signs of aging, and I feel it is important to explain my recommendations, which are all scientifically based. As I nursed a cup of green tea and read the news on the Internet, a 24-point-type headline from the United Kingdom’s Financial Times caught my eye: “Scientists discover the secret of ageing.” The article explained how one of the biggest puzzles in biology—how and why living cells age—had been solved by an international team based at the United Kingdom’s Newcastle University. Using a complex “systems biology” approach, the researchers, in conjunction with scientists from the University of Ulm in Germany, had set out to discover why cells become senescent, or, in other words, grow old. The research, published by the journal Molecular Systems Biology, showed that when an aging cell detects serious DNA damage, which may be the result of general wear and tear from daily living, it sends out internal signals. These distress signals trigger the cell’s mitochondria, the energy-producing part of the cell, to make free-radical molecules, which instruct the cell either to destroy itself or to stop dividing. The reason for this is to avoid the damaged DNA that results in cancer. As you will discover in these pages, I am convinced that the damaging diseases and cellular destruction associated with aging begin with the mitochondria. I concur with the research findings from Newcastle University, as they validate my own research regarding how and why we age. The release of this study just as I was delivering my manuscript to my publisher was very exciting, because the researchers’ discovery echoes the underlying theme of this book. I have gone beyond the science of why we age to search for practical ways to intervene in the process. In Forever Young you will learn new, effective, and safe strategies to protect the mitochondria, the mitochondrial DNA, and other parts of the cell from this programmed cell death, known as apoptosis, starting with the miraculous therapeutic powers of niacinamide (vitamin B3), which you will read about on page 107. A New Model for Understanding Aging My first experience with seriously ill patients occurred when I was a medical student at Michigan State University College of Medicine. During my rotation in internal medicine, particularly the weeks spent in the intensive care unit, I became intimately familiar with sepsis, one of the most common causes of death. Also known as gram-negative bacteremia and gram-positive bacteremia, sepsis occurs when infectious agents like bacteria or fungi or products of infection like bacterial toxins enter the body, most often through a wound or incision. If this systemic infection goes unchecked, it leads to a condition known as septic shock, resulting in hypotension, or extremely low blood pressure; dysregulation of blood sugar; and the failure of such multiple organ systems as the heart, kidney, liver, and lungs. The Sepsis/Inflammation/Aging Connection In 1981 when I was in medical school, I was trying to understand what caused underlying damage to the vital organs during septic shock. The question was a huge challenge for both physicians and scientists. The research indicated that metabolic changes occurring on a cellular level were the primary cause of organ dysfunction and failure. The consensus was that these fundamental metabolic disturbances were the result of inadequate tissue oxygenation and a disruption of the body’s ability to control blood sugar levels. This combination of symptoms came to be known as multiple organ dysfunction syndrome, or MODS. It was widely hypothesized that multiple organ dysfunction syndrome resulted from tissue hypoxia, a condition in which vital organs do not get enough oxygen to meet their needs. Fast-forward to a new millennium: the concept of inadequate oxygen levels to vital organs as the fundamental cause of MODS is now being seriously questioned. Today, scientists believe that adequate oxygen is delivered to the vital organs by the bloodstream during sepsis and septic shock. The problem is that the cells are unable to use that oxygen, even though it is being supplied at adequate levels. The inability of the vital organs to utilize oxygen is a cellular malfunction in the tiny organelles known as the mitochondria. This impaired cellular oxygen problem is termed cytopathic hypoxia. Just as cytopathic hypoxia is far more important in the generation of MODS than had ever been thought in the past, I propose that cytopathic hypoxia, as seen in the cellular changes of aging, is far more important to the degeneration of the organ systems than was previously believed. Having come to that conclusion, I had to ask the next question: If cells cannot utilize the oxygen, where in the cell is the defect? The answer is the mitochondria. The Mighty Mitochondria The mitochondria are tiny energy-generating parts of the cell. They function as microscopic furnaces, converting food into fuel, and are responsible for all energy production in the body. The majority of the oxygen supplied to the cell is utilized by the mitochondria to make a chemical known as adenosine triphosphate, or ATP. ATP is the energy storage and transfer molecule that is essential to life. As I discussed in one of my previous books, Dr. Perricone’s 7 Secrets to Beauty, Health, and Longevity, functioning mitochondria are vital to maintaining a healthy body and beautiful skin. A Closer Look at Mitochondrial Function Although tiny, the mitochondria play a huge role in the body as the energy-producing portion of the cell. To accomplish this feat, they consume 90 percent of the oxygen that is needed by our bodies. As mentioned, this oxygen is used to oxidize fuel or burn food to synthesize ATP, which is the energy currency of the cell. This process of ATP production in the mitochondria is known as oxidative phosphorylation and takes place in the part of the mitochondria known as the electron transport chain. Within the electron transport chain, ATP is produced in five steps. If anything disrupts this chain, free radicals are created; this further disrupts the electron transport chain, causing irreparable damage to the mitochondria. Damage to the mitochondria and disruption of the electron transport chain are the first events seen in sepsis. Unchecked, this results in total systemic collapse, multiple organ failure, and death. Although it may seem counterproductive, the energy produced by the mitochondria is the major source of free-radical production in the cells. This is a result of the metabolic process that converts food and oxygen to water and ATP. As energy production takes place in the electron transport chain, within the mitochondrial membrane, about 5 percent of the electrons escape. This creates free radicals that damage both the mitochondria and the cell. Note FREE-RADICAL CHEMISTRY Many people are confused about free radicals. They know that they are bad and that antioxidants combat them. Understanding the chemistry of free radicals will give you an important perspective on aging. Atoms and molecules are most stable when there is a pair of electrons circulating in their outer orbit. When a molecule or atom loses one of the electrons, it becomes a free radical. Its mission in life has now become the quest for another atom or molecule to hook up with. Any substance that rips electrons away from another molecule is known as an oxidizing agent or electrophile. Free radicals can damage tissues, cell membranes, and DNA, disrupting our store of genetic information, which may lead to the initiation of certain cancers. Free radicals can also oxidize the fats that make up the cell wall membrane and the membrane covering the mitochondria and the nucleus. This oxidation can lead to cellular dysfunction and serious damage to the immune system and major organs such as the brain, heart, kidneys, and pancreas. Free radicals contribute to at least fifty major diseases, including atherosclerosis, heart disease, rheumatoid arthritis, and lung disease, as well as accelerated aging. Although free radicals exist for only a fraction of a second, the inflammatory cascade that they generate goes on for hours or days. Antioxidants, including vitamin C, alpha-lipoic acid, and Co Q10, are known as reducing agents. They neutralize free radicals and leave a much more benign antioxidant free radical in its place. Unfortunately, the mitochondria are a site of constant free-radical production (see page 6) and very susceptible to the damage that free radicals can cause. If we hope to preserve youthful function and prevent disease, it is critical to search for agents and antioxidants that will protect the mitochondria from free-radical damage. Therapeutic Strategies for the Mitochondria in Disease and Aging Although the concept that free radicals are responsible for triggering an inflammatory response on a cellular and molecular level was considered with skepticism when I introduced it in The Wrinkle Cure, it is now dogma accepted by even the most conservative scientists. The idea that free radicals and inflammation cause cellular...

Most helpful customer reviews 78 of 80 people found the following review helpful. Excellent and a little frustrating By Blazing Pascal First, I really like this book. It's full of excellent information that, when you think about it, just makes sense. I am glad I got the book and would recommend it to anyone (I am waiting for my second copy to give away as I write this).That said, as a 37 year old man looking to lose about 45 pounds, the book has also been a little frustrating. First, I realize that women are the target market here, but it would be nice to have a few pages directed at the guys out there. Second, and more importantly, I really needed to see a simple summary and a clear regimen stated somewhere. Every chapter is full of excellent information, but I feel as if I have to pick and choose and piece it together myself in order to make it (hopefully) work for me.I was glad to see there was a relatively clear guide to making the Meal Replacement Drink, but even then, it could have been clearer. After spending some time describing the benefits of egg white albumin, the recipe says, "I suggest 6 ounces of the protein source in liquid form or as labeled if it is in powdered form." Powdered form? I assume he recommended 6 ounces of egg whites as the liquid source, but now I have to figure out what "powdered form" means and if I was correct about the egg whites. I am sure some research will help me here, but it would have been nice to just be told plain and simple. Add to that, the six ounce recommendation is for a "women approximately five feet, four inches tall with moderate activity..." What about a guy about 5'11" with less than moderate activity? In the same recipe, he says to mix 1 teaspoon of non-Dutch cocoa with stevia and *a little water*, what is "a little water?" Again, I realize this might be a "to taste" thing, but I would have liked a place to start.There is a great section talking about glutathione and the topical solution that solves the problem of adequate transport. I am very excited to try this, but I can't figure out where it is. I am now thinking that it is not out yet. I may be mistaken though. I'm still trying to figure it out. I watched the PBS special where he talked a lot about the wonder of this topical and I assumed it was available. Just not sure yet.The recipes look very good - and that is coming from someone with terrible sensory issues and food aversions. There are a few tweaks I will have to make, but I have also been encouraged to "just eat it" with most of the ingredients. While I am not into Yoga, the section is very well done and about as engaging as it could be. The poses, etc. are all explained well and I will glad to see a few "programs" listed, at least two of which I am looking forward to trying.Ultimately, I think I will have to call one of their counselors and see if they can help me. I am weak and tired and anxious to try this. The claims to not only help you lose weight but improve mood and overall health are very motivating for me. That said, I do not want to end up wondering if I am doing it right. That is terribly frustrating. Sometimes I felt as if the author was assuming I knew something already.I would have given the book 5-stars had it, 1) provided at least a little guidance for a man reading this, 2) provided a "cheat sheet" of sorts plainly stating proper summarized regimens for both the diet and the supplement usage. I think that most of the information I need is in there, somewhere. I just wish I didn't have to work so hard to bring it all together.One last thing: while Dr. Perricone does offer up his own products in here, I never felt as if he was forcing me to get his stuff. He also suggests a variety of other venders (though he may have relationships with them too, I don't know), and many of the supplements, etc. he recommends can be purchased just about anywhere. I really wish his weight management supplement pack was not $200 a month. : ( Budgeting it one thing,